WebOct 15, 2012 · The ‘funny’ (pacemaker, I f) current, first described almost 30 years ago in sinoatrial node (SAN) myocytes, is a mixed sodium/potassium inward current, activated …
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The pacemaker current (If, or IKf, also called funny current) is an electric current in the heart that flows through the HCN channel or pacemaker channel. Such channels are important parts of the electrical conduction system of the heart and form a component of the natural pacemaker. First described in the late … See more The funny current is highly expressed in spontaneously active cardiac regions, such as the sinoatrial node (SAN, the natural pacemaker region), the atrioventricular node (AVN) and the Purkinje fibres of … See more A similar current, termed Ih (hyperpolarization-activated), has also been described in different types of neurons where it has a variety of functions, including the contribution to control of rhythmic firing, regulation of neuronal excitability, sensory … See more Because of their relevance to generation of pacemaker activity and modulation of spontaneous frequency, f-channels are natural targets of drugs aimed to pharmacologically control heart rate. Several agents called "heart rate reducing agents" act by … See more The molecular determinants of the pacemaker current belong to the HCN channel (hyperpolarization-activated cyclic nucleotide–gated channel), of which 4 isoforms (HCN1 … See more • Pacemaker potential • Cardiac pacemaker • Cardiac action potential See more WebFeb 1, 2010 · The depolarizing "funny" current If, which has an important role in the control of excitability by being involved in the adjustment of the depolarization phase in pacemaker cells (phase 4 of AP ... how fast do you increase sodium
Pacemaker channels - PubMed
WebPhysiology and pharmacology of the cardiac pacemaker ("funny") current First described over a quarter of a century ago, the cardiac pacemaker "funny" (I(f)) current has been extensively characterized since, and its role in cardiac pacemaking has … WebThe pacemaker "funny" current (I (f)) has been the object of detailed investigations since its original description in sinoatrial node myocytes in the late 1970s; its role in underlying generation of spontaneous activity and autonomic modulation of cardiac rate has been amply demonstrated. WebThe Role of The Funny Current in Pacemaker Activity Ca2 Cycling in the Mechanism of Pacemaking Cardiac Pacemaking: Historical Overview and Future Directions Dennis Noble, Guest Editor, and Brian O’Rourke, Editor ... Key Words: pacemaking funny current rate modulation sinoatrial node HCN channels S elf-sustained contractile activity is a ... how fast do you push benadryl iv