Half life of benefix
BeneFIX®, Coagulation Factor IX (Recombinant), is a human blood coagulation factor indicated in adults and children with hemophilia B (congenital factor IX deficiency or Christmas disease) for: o 1. On-demand … See more For intravenous use after reconstitution only. • 1. Each vial of BeneFIX has the recombinant Factor IX (rFIX) potency in the International … See more BeneFIX is contraindicated in patients who have manifested life-threatening, immediate hypersensitivity reactions, including anaphylaxis, to the product or its components, … See more BeneFIX is supplied as a white lyophilized powder in the following nominal dosages: • 1. 250 IU • 1. 500 IU • 1. 1000 IU • 1. 2000 IU • 1. 3000 IU Each BeneFIX single-use vial has the actual recombinant factor IX (rFIX) potency in the … See more WebINDICATIONS AND USAGE. BeneFIX is a recombinant human blood coagulation factor IX indicated for adults and children with hemophilia B (congenital factor IX deficiency or Christmas disease) for: On-demand treatment and control of bleeding episodes. ( 1) Perioperative management of bleeding.
Half life of benefix
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WebHalf-life: 25.4-26.7 hr; Clearance: 6-6.4 mL/kg/hr; BeneFIX. Half-life: 18.1-22.4 hr (adults); 19.8 hr (children 2-12 years); 21.1 hr (children 12-15 years) Clearance: ~8.5 mL/kg/hr; … http://www.hemophilia.ca/files/Alprolix%20-%20EN.pdf
WebBeneFIX pharmacokinetic parameter of terminal half-life was assessed and compared to the AlphaNine pharmacokinetic parameter (PK2 Study). Time Frame Baseline (prior to the infusion), and at 15 and 30 minutes, 1, 3, 6, 9, 24, 48, 72, and 74 hours following a single dose infusion of BeneFIX administered following a 7 to 15 day wash-out period. WebFor long-term prophylaxis against bleeding, the recommended regimen is 100 IU/kg once weekly. Children (<12 years) have lower recovery, shorter half-life and higher clearance …
WebThe median elimination half-life for the PTP surgery subjects was 19.4 hours (range 10–37 hours; mean 21.3 ± 8.1 hours). Table 8: Efficacy of BeneFIX for Surgical Procedures in … WebJan 16, 2024 · BeneFIX IV Minor bleeding (e.g., uncomplicated hemarthroses, superficial muscle, soft tissue): Administer appropriate dose to achieve factor IX levels of 20–30% …
Webparameters, such as half-life and recovery, as well as the clinical situation (see section 4.4). In an eleven patient crossover, randomised pharmacokinetic evaluation of BeneFIX and …
Webpharmacokinetic(e.g., half-life, recovery) and clinical responses to BeneFIX. Although the dose can be estimated by the calculations above, it is highly recommended that, … rudolf hess his betrayal and murderWebAlphaNine SD, BeneFix, Ixinity, Mononine, and Rixubis are standard half-life factor IX products for the treatment and prevention of bleeding in patients with hemophilia B. … scan with canon pixma mg2522WebMar 27, 2024 · Mean Difference of Terminal Half-Life: BeneFIX Compared to AlphaNine [ Time Frame: Baseline (prior to the infusion), and at 15 and 30 minutes, 1, 3, 6, 9, 24, 48, … rudolf hess eagleshamWebThe median cost for 30 days of prophylaxis of an average 25-kg 8-year-old child at the current University of Iowa Price (0.87 US dollars Mononine/0.86 US dollars BeneFix as of December 2002) if given every third day would be 19,972 US dollars and 34,456 US dollars for r-FIX. However, because of wide inter-patient variability in recovery and ... rudolf hickelrudolf hess flies to scotlandWebBeneFix: A recombinant factor IX for treating spontaneous bleeds (prophylaxis) and preventing bleeds during surgery and postoperatively in patients with haemophilia. … scan with canon pixma mx492WebOn-demand treatment and control of bleeding episodes. Perioperative management of bleeding. Patients 16 years of age and older with hemophilia B (congenital factor IX … scan with canon pixma