WebMay 28, 2024 · Here, we present additional efficacy, safety, and quality-of-life (QoL) data from CheckMate 577. Results: 794 pts were randomized (NIVO, 532; PBO, 262). Distant … WebAug 11, 2024 · About CheckMate -577. CheckMate -577 is a Phase 3 randomized, multi-center, double-blind study evaluating Opdivo as an adjuvant therapy in patients with resected esophageal or GEJ cancer who have received neoadjuvant CRT therapy and have not achieved a pathological complete response. The primary endpoint of the trial is DFS …
Update Supports Adjuvant Nivolumab as Standard Care …
WebJan 22, 2024 · 167 Background: NIVO is the first adjuvant therapy to provide a statistically significant and clinically meaningful improvement in disease-free survival (DFS) versus PBO in resected EC/GEJC following neoadjuvant chemoradiotherapy as demonstrated by CheckMate 577. NIVO was well tolerated with an acceptable safety profile. This analysis … WebAug 14, 2024 · Immunotherapy after Chemoradiation and Surgery In one trial, called Checkmate-577, patients with both Esophageal Adenocarcinoma and Esophageal Squamous Cell Carcinoma were … taunton early intervention
Adjuvant immunotherapy in resected esophageal squamous
WebMay 12, 2024 · The CheckMate -648 data are part of the official ASCO press program on May 28, 2024. Expanded efficacy and safety results from CheckMate -577, the first and only trial to demonstrate superior efficacy of Opdivo monotherapy in the adjuvant setting in patients with esophageal or gastroesophageal junction cancer. WebJun 2, 2024 · Ronan J. Kelly, MD, MBA, Baylor Scott & White Health, Dallas, Texas, discusses the expanded efficacy and safety analysis from Checkmate 577; a Phase III study of adjuvant nivolumab in patients with esophageal and gastroesophageal junction cancer (EC/GEJC) who have residual pathologic disease after receiving neoadjuvant … WebKelly et al. conducted CheckMate 577, a global, randomized, double-blind, placebo-controlled phase 3 trial that evaluated the use of a checkpoint inhibitor as adjuvant … taunton electricity