2024 Car.70/il15-transduced cb-nk cells

Car.70/il15-transduced cb-nk cells

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August undefined, 2024

WebFull Description. Primary Objective: To determine the safety, efficacy and optimal cell dose of CAR.70/IL15-transduced CB-NK cells in patients with relapse d/refractory … WebNKX101 is a novel investigational NK cell therapy, engineered to augment the innate anti-tumor biology of NKG2D. NKG2D is an activating receptor found on naturally occurring NK cells that triggers the targeted killing of stressed and cancerous cells. AML is a blood cancer that disrupts the production of normal blood cells in the bone marrow.

Phase I/II Study of CAR.70- Engineered IL15-transduced …

WebCyclophosphamide, CAR.70/IL15-transduced CB-NK cells, Fludarabine phosphate Description The goal of this clinical research study is to learn about the safety of giving … WebDec 1, 2024 · Natural killer cells (NK cells) are the first line of the innate immune defense system, primarily located in peripheral circulation and lymphoid tissues. They kill virally … rattlesnake\\u0027s vw

Multiple Myeloma Clinical Trial: Phase I/II Study of CAR.70

WebFully human anti CD19 CAR-T Cell Dose for Non-Hodgkin's Lymphoma. ... UB_TT170 for Osteosarcoma. CAR.70/IL15-transduced CB-NK cells for B-Cell Lymphoma. SCRI-CAR22v2 for Lymphoma. PBCAR0191 for … WebMar 29, 2024 · Study of CAR.70-engineered IL15-transduced Cord Blood-derived NK Cells in Conjunction With Lymphodepleting Chemotherapy for the Management of … WebWe transduced CB-derived NK cells with a retroviral vector incorporating the genes for CAR-CD19, IL-15 and inducible caspase-9-based suicide gene (iC9), and demonstrated … dr tara brosnick

NKG2D-CAR-transduced natural killer cells efficiently …

Cord blood NK cells engineered to express IL-15 and a CD19-targeted CAR ...

WebOUTLINE: This is a phase I, dose-escalation study of CAR.CD19-CD28-zeta-2A-iCasp9-IL15-transduced CB-NK cells followed by a phase II study. Participants receive rituximab intravenously (IV) over 3 hours on days -14 and -8, carmustine IV over 2 hours on day -13, etoposide IV over 3 hours twice daily (BID) on days -12 to -9, cytarabine IV over 1 ... WebDec 7, 2024 · Notably, CAR expression was stable over time. iC9/CAR.123/IL15+ and iC9/hCAR.123/IL15+ NK cells expanded for 2 weeks showed no signs of exhaustion, such as downregulation of eomesodermin and T-bet, or upregulation of KLRG1, and exhibited a mature phenotype, similar to ex vivo expanded non-transduced NK cells (NT-NK) using … rattlesnake\u0027s vyWebFeb 4, 2024 · The central hypothesis of this study predicts that knocking out the CISH gene in CAR-NK cells will enhance their effector function against tumor cells, much in the way that targeting PD-1 improves outcomes by removing a critical immune checkpoint in T cells. 20, 21 Our approach for combined retroviral transduction with the iC9/CAR19/IL-15 … rattlesnake\u0027s vw

"WebEmbodiments of the disclosure include methods and compositions related to targeting of CD70-expressing cells with NK cells specifically engineered to bind the CD70 antigen. In par " - Car.70/il15-transduced cb-nk cells

Car.70/il15-transduced cb-nk cells

Cord Blood NK Cells Engineered to Express a Humanized CD123 …

WebPhase 1 Phase 2 Phase 3 Phase 4 N/A. Start Date. Organizations. Indications. NCT05092451. Phase 1/Phase 2. 11/30/2024. University of Texas at Houston. … WebUmbilical & Cord Blood (CB) Derived CAR-Engineered NK Cells for B Lymphoid Malignancies. Latest version (submitted April 4, 2024) on ClinicalTrials.gov. A study version is represented by a row in the table. Select two study versions to compare. One each from columns A and B.

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WebDec 1, 2024 · Natural killer cells (NK cells) are the first line of the innate immune defense system, primarily located in peripheral circulation and lymphoid tissues. They kill virally infected and malignant cells through a balancing play of inhibitory and stimulatory receptors. In pre-clinical investigational studies, NK cells show promising anti-tumor effects and are … WebFeb 1, 2024 · Cord blood (CB) offers an attractive, allogeneic, off-the-self source of NK cells for immunotherapy. We transduced CB-derived NK cells with a retroviral vector incorporating the genes for CAR-CD19, IL-15 and inducible caspase-9-based suicide gene (iC9), and demonstrated efficient killing of CD19-expressing cell lines and primary …

WebFeb 7, 2024 · NK cells were transduced with a retroviral vector expressing genes that encode anti-CD19 CAR, interleukin-15, and inducible caspase 9 as a safety switch. The cells were expanded ex vivo and ... WebOct 25, 2024 · Conditions: B-Cell Lymphoma; Myelodysplastic Syndromes (MDS); Acute Myeloid Leukemia (AML) Interventions: Drug: Cyclophosphamide; Drug: CAR.70/IL15-transduced CB-NK cells; Drug: Fludarabine phosphate Sponsor: M.D. Anderson Cancer Center Not yet recruiting...

WebJan 17, 2024 · To determine the antitumor activity of CAR.70/IL15-transduced CB-derived NK cells. Although the clinical benefit of CAR.70/IL15-transduced CB-derived NK cells has not yet been established, the intent of offering this treatment is to provide a possible therapeutic benefit and thus, the patient will be carefully monitored for tumor response …

WebJul 20, 2024 · We transduced CB-derived NK cells with a retroviral vector incorporating the genes for CAR-CD19, IL-15 and inducible caspase-9-based suicide gene (iC9), and demonstrated efficient killing of CD19 ...

WebApr 28, 2024 · T cells engineered to express chimeric antigen receptors (CARs) have revolutionised the field of cellular therapy for cancer. Despite its success, this strategy … rattlesnake\\u0027s vyWebIL-15 production and phenotype of iC9/CAR.19/IL15-transduced CB-NK cells (A) IL-15 production by NT-NK cells or CAR transduced NK cells cultured in the presence or … dr tara ostrom azWebOct 25, 2024 · Drug: Cyclophosphamide Drug: CAR.70/IL15-transduced CB-NK cells Drug: Fludarabine phosphate. Phase 1 Phase 2. Detailed Description: Primary Objective: … dr tara narula bioWebApply to this Phase 1 & 2 clinical trial treating Advanced Renal Cell Carcinoma (aRCC), Advanced Mesothelioma, Advanced Osteosarcoma. Get access to cutting edge treatment via CAR.70/IL15-transduced CB-derived NK cells, Cyclophosphamide, Fludarabine phosphate. View duration, location, compensation, and staffing details. rattlesnake\u0027s w2WebAug 14, 2024 · Over 70% of human cancers upregulate NKG2D ligand ... Macapinlac HA, Thompson P, Basar R, et al. Use of CAR-transduced natural killer cells in CD19-positive lymphoid tumors. N Engl J Med. 2024;382 ... dr tara plansky newton njWebPhase I/II Study of CAR.70- Engineered IL15-transduced Cord Blood-derived NK Cells in Conjunction With Lymphodepleting Chemotherapy for the Management of Relapse/Refractory Hematological Malignances Latest version (submitted January 24, 2024) on ClinicalTrials.gov dr tara narula photosWebApr 28, 2024 · Our group has investigated fourth-generation CB-derived CAR-transduced NK cells. ... cell survival pathways and decreased apoptosis. 70 NK-92MI cells have been modified by lentiviral transduction to express a first-generation ... (anti-CD19CAR.IL15.iCas9). Eleven heavily pretreated patients with CD19-positive cancers, … rattlesnake\u0027s vx